I've nominated Hand of Isis by Jo Graham, which has as one of the central three characters Iras. Hand of Isis is set in Alexandria, Egypt, in Cleopatra's time. Iras is mixed race, her father was Ptolemy, her mother was Nubian.

Jim Butcher also has The Dresden Files, which is mostly full of white characters. But there is Ramirez and Susan, who are both Latino, and Sanya, who is black and Russian.